In brief: MSM (methylsulfonylmethane) is an organosulfur compound mainly marketed for joint health.
What do studies show?
| Question | Interpretation |
|---|---|
| Knee osteoarthritis | Small RCTs with mixed results |
| Pain | Possible small effects |
| Long-term benefit | Unclear |
| Optimal dose | Not clearly established |
One randomised trial found small improvements of uncertain clinical importance.[1] A meta-analysis did not show a convincing overall effect.[2]
Safety
Gastrointestinal symptoms, headache or skin reactions can occur. Long-term data are limited.
FAQ
Does MSM cure osteoarthritis?
No.
Is MSM the same as DMSO?
No.
Is more MSM more effective?
That is not established.
Can MSM replace medication?
No.
Conclusion
MSM may be of interest to some people, but it is not an established osteoarthritis medicine.
