In brief: The term “adrenal fatigue” claims that chronic stress exhausts the adrenal glands. This is not a recognised diagnostic model. True adrenal insufficiency, by contrast, is a defined medical condition.
Adrenal fatigue versus adrenal insufficiency
| Topic | Adrenal fatigue | Adrenal insufficiency |
|---|---|---|
| Recognised diagnosis | No | Yes |
| Standard tests | No | Yes |
| Hormone replacement | Not indicated | Can be lifesaving |
True adrenal insufficiency
The Endocrine Society describes standard evaluation using clinical context, cortisol/ACTH and, when needed, stimulation testing.[1]
Think more broadly about fatigue
Sleep apnoea, anaemia, thyroid disease, depression, medicines, infection and chronic illness are more established explanations for persistent tiredness.
FAQ
Is adrenal fatigue real?
The symptoms are real, but the model is not a recognised diagnosis.
Can stress change cortisol?
Yes, but that does not prove an “exhausted” adrenal gland.
Are saliva home tests enough?
No.
Can steroid medicines be stopped abruptly?
No.
Conclusion
Adrenal fatigue is a simple explanation for complex symptoms. Targeted assessment for recognised causes is more useful.
